Triapine With Chemotherapy and Radiation Therapy in Treating Patients With IB2-IVA Cervical or Vaginal Cancer
Status:
Recruiting
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
This phase I trial studies the side effects and best dose of triapine when given with
radiation therapy and cisplatin in treating patients with stage IB2-IVA cervical or vaginal
cancer. Triapine may stop the growth of cancer cells by blocking an enzyme needed for cell
growth. Cisplatin is a drug used in chemotherapy that kills cancer cells by damaging their
deoxyribonucleic acid (DNA) and stopping them from dividing. Radiation therapy uses
high-energy x-rays to kill tumor cells and shrink tumors. Adding triapine to standard
treatment with cisplatin and radiation therapy may kill more cancer cells.