Tripe Versus Dual Antiretroviral Therapy in HIV-infected Patients With Virological Suppression (Tridual)

• Status: Completed
• Trial end date: 2021-02-03
• Target enrollment: 0
• Participant gender: All

Summary

The persistence of an aberrant state of immune activation and inflammation (pIA) may contribute to the emergence of serious non-AIDS events which carry a higher morbimortality in HIV-infected patients. Although combined antiretroviral treatment (cART) reduces both cellular and soluble activation markers, it fails to completely control pIA despite consistent plasma viral load suppression. One of the mechanisms involved in pIA is may be an incomplete suppression of viral replication not reflected by plasma viral load, which only reflects a balance between viral replication and clearance of HIV-RNA. In addition, low-level viremia detected in most HIV-1-infected patients despite years on cART. Unintegrated 2-LTR HIV-DNA, and cellular associated HIV-RNAs, as products of active integrated DNA transcription, support this issue.

Furthermore, the key rationales behind simplifying cART are a reduction of toxicities, lower risk of resistance mutations in case of virological failure and saving costs. One of these simplification strategies is a dual therapy which, based on the data up to date and in our clinical experience, has similar virological efficacy than cART. However, it is unknown if this strategy could increase the persistent HIV-1 replication and, therefore, pIA. The CD4+/CD8+ T cell ratio as a marker of immune recovery, the changes in T cell immune activation, senescence, exhaustion and apoptosis, and the cellular associated HIV-DNA and -RNA would answer the question if simplification to dual therapy would provide less control of residual HIV replication and, therefore, a detriment on pIA compared to triple therapy and, therefore, would worsen the patients' long-term prognosis.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hospitales Universitarios Virgen del Rocío
• Collaborators: Fundación Pública Andaluza para la gestión de la Investigación en Sevilla; Instituto de Salud Carlos III
• Treatments: Cobicistat; Dolutegravir; Lamivudine

Criteria

Inclusion Criteria:

• HIV-1-infected patients ≥ 18 years of age.

• Starting date of antiretroviral treatment later than 01/01/2010

• Plasma HIV-1 RNA <20 copies/ml for at least one year on triple therapy

• Antiretroviral treatment based on an integrase inhibitor plus two nucleos(t)ide analogs in the last 6 months.

• Signed written informed consent prior to inclusion.

Exclusion Criteria:

• Primary resistance to any of the drugs included in the study.

• Active opportunistic infection.

• Pregnancy at inclusion or during the follow-up

• Active hepatitis C and/or B virus co-infection.

• Cirrhosis, portal hypertension and/or hypersplenism of any etiology.

• Current or past malignancies subsidiary of treatment with corticosteroids, immunomodulatory agents, interferon or chemotherapeutic agents.

• Any laboratory abnormality grade 3 or 4 according to the U.S. Department of Health and Human Services, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Division of AIDS.

• Concomitant use of drugs with potential major interactions with the prescribed drugs according to the respective full prescribing information.

• Estimated creatinine clearance <50 ml/min