Troponin I Release After High Diuretic Doses

• Status: Completed
• Trial end date: 2011-09-01
• Target enrollment: 0
• Participant gender: All

Summary

High values of cardiac troponin (Ct) in acute heart failure (ADHF) identify patients (pts) at higher risk and worsened prognosis. A Ct increase during therapy indicates the need for more appropriate intervention, aimed at compensating cardiac disease and effectively minimizing myocardial wall stress and subsequent cytolysis. This study evaluated the effects of an intravenous high-dose of furosemide with or without small-volume hypertonic saline solution (HSS)on myocardial cytolysis in ADHF pts.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Palermo
• Treatments: Diuretics; Furosemide

Criteria

Inclusion Criteria:

• signs/symptoms of heart failure;

• New York Heart Association (NYHA) functional Class III or IV on admission due to an exacerbation of symptoms with at least 1 class deterioration;

• evidence of systolic dysfunction on echocardiographic examination on admission (EF<45%);

• BNP levels on admission > 100pg/mL

Exclusion Criteria:

• NYHA class < III on admission or without a NYHA class improvement on discharge;

• acute coronary syndrome,

• pulmonary thromboembolism,

• cardiac tamponade,

• pericarditis,

• renal insufficiency (serum creatinine <2,5 mg/dL, BUN <60 mg/dL) or those on dialysis;

• chronic liver disease,

• pleuro-pneumonia,

• blood and autoimmune diseases,

• concomitant other important co-morbidity,

• cerebral vascular disease,

• dementia,

• cancer,

• uncompensated diabetes,

• took non-steroid anti-inflammatory drugs (NSAID)

• declining to provide informed consent,

• patients requiring pacemaker implantation and those with issues of excessive alcohol consumption