Tumescent Antibiotic Delivery for Prevention of Surgical Site Infection
Status:
Unknown status
Trial end date:
2019-12-01
Target enrollment:
Participant gender:
Summary
The principal aim of the present research is to compare two methods of antibiotic delivery:
concomitant tumescent antibiotic delivery (TAD) and intravenous antibiotic delivery (IVAD)
versus IVAD alone, (TAD+IVAD vs IVAD), with respect to the prevention of surgical site
infections (SSI). The investigators hypothesize that TAD+IVAD will significantly reduce the
incidence of SSI compared to IVAD.
TAD is the subcutaneous infiltration of a dilute solution of antibiotic(s) in a solution of
tumescent local anesthesia (TLA). TLA consists of a dilute solution of lidocaine (1gm/L),
epinephrine (1mg/L) and sodium bicarbonate (10mEq/L) in 0.9% physiologic saline.
A secondary aim of this study is to compare TAD+IVAD vs IVAD with respect to the prevention
of post-operative venous thromboembolism (VTE).