Turning Dexmedetomidine Into a Powerful Anesthetic That Can be Rapidly and Completely Reversed

• Status: Not yet recruiting
• Trial end date: 2026-05-01
• Target enrollment: 0
• Participant gender: All

Summary

In this study, the investigators will explore Atipamezole & caffeine's ability to facilitate the emergence from anesthesia. Each subject will visit UChicago 4 times. The first time for informed consent. The second time for a complete physical exam to ensure that the subjects are healthy. Then there are 2 sedation sessions. Subjects get an honorarium for each sedation session.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Chicago
• Treatments: Atipamezole; Caffeine; Dexmedetomidine

Criteria

Inclusion Criteria:

1. Age >21 or <40

2. ASA physical status = 1 (normal healthy patient without systematic diseases or conditions)

3. Metabolic Equivalents of Functional Capacity (METs) > 5

4. Low risk for Obstructive Sleep Apnea (OSA) based on the screening test (STOP-bang score established by American Society of Sleep Apnea): Yes to < 3 items- high risk of OSA

5. No history Arrhythmia, such as heart block (Baseline EKG will be obtained during the history and physical session), seizure, liver and kidney diseases

6. BMI <30 kg/m2

7. No history of any mental illness

8. No history of drugs or alcohol abuse (an urine drug screen test required)

Exclusion Criteria:

1. Age <21 or >40

2. ASA physical status > 1 (normal healthy patient with systematic diseases or conditions)

3. Metabolic Equivalents of Functional Capacity (METs)<5

4. High risks for Obstructive Sleep Apnea (OSA) based on the screening test (STOP-bang score established by American Society of Sleep Apnea): Yes to > 3 items- high risk of OSA

5. History Arrhythmia (Baseline EKG will be obtained during the history and physical session), seizure, liver and kidney diseases

6. BMI >30 kg/m2

7. History of any mental illness

8. History of drugs or alcohol abuse (an urine drug screen test required)

9. Female subjects with positive urine pregnancy test, which will be performed before each sedation session