Two Different Antibiotics Versus One Antibiotic for Pediatric Perforated Appendicitis
Status:
Unknown status
Trial end date:
2020-12-22
Target enrollment:
Participant gender:
Summary
After appendix has been removed for perforated appendicitis, patients will receive
postoperative antibiotics. In the last 5 years, the literature has transitioned from a 3
-drug therapy to 2-drug therapy. Now there is a recent literature suggesting a single-drug
therapy may be safe and adequate. In fact, using zosyn (piperacillin-tazobactam) as a
single-drug therapy, there are additional benefits of simplicity, compliance, and lower
infectious complications. Currently surgeons are already using both 2-drug regimen
(ceftriaxone/metronidazole) and single-drug regimen (zosyn) interchangeable as both are FDA
approved and regulated antibiotics for intra-abdominal infection. There is a clear need to
compare outcomes between these two options.