Two Different Antibiotics Versus One Antibiotic for Pediatric Perforated Appendicitis

• Status: Unknown status
• Trial end date: 2020-12-22
• Target enrollment: 0
• Participant gender: All

Summary

After appendix has been removed for perforated appendicitis, patients will receive postoperative antibiotics. In the last 5 years, the literature has transitioned from a 3 -drug therapy to 2-drug therapy. Now there is a recent literature suggesting a single-drug therapy may be safe and adequate. In fact, using zosyn (piperacillin-tazobactam) as a single-drug therapy, there are additional benefits of simplicity, compliance, and lower infectious complications. Currently surgeons are already using both 2-drug regimen (ceftriaxone/metronidazole) and single-drug regimen (zosyn) interchangeable as both are FDA approved and regulated antibiotics for intra-abdominal infection. There is a clear need to compare outcomes between these two options.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Phoenix Children's Hospital
• Treatments: Anti-Bacterial Agents; Antibiotics, Antitubercular; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Tazobactam

Criteria

Inclusion Criteria:

• Postoperative Perforated Appendicitis (documented by intraoperative photo)

• Postoperative Laparoscopic Appendectomy

Exclusion Criteria:

• Nonperforated Gangrenous Appendicitis

• Nonperforated Purulent Appendicitis

• Open Appendectomy