Two Dose Epidural Morphine for Post-cesarean Analgesia

• Status: Terminated
• Trial end date: 2014-06-01
• Target enrollment: 0
• Participant gender: Female

Summary

The investigators aim to assess the analgesic effect of a two-dose epidural morphine regimen for 2nd day post-cesarean pain, as part of a multimodal analgesia regimen, which includes scheduled Nonsteroidal anti-inflammatory drugs (NSAIDs). The investigators hypothesize that administration of a second dose of epidural morphine 3 mg, 24 hours after an initial intraoperative dose, will provide superior post-cesarean analgesia during the 2nd 24 hours after surgery, compared to a single epidural morphine dose regimen. The primary outcome will be the amount of intravenous morphine patients self-administer during the 2nd 24 hours post-surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Columbia University
• Treatments: Morphine

Criteria

Inclusion Criteria:

• Women undergoing cesarean section under epidural anesthesia.

Exclusion Criteria:

• Emergent cesarean section

• Coagulopathy

• Failed epidural anesthesia or patchy block

• General anesthesia

• Use of epidural chloroprocaine

• Allergy or contraindication to Non-steroidal anti-inflammatory drug (NSAIDs)

• Severe opioid side effects

• History of chronic opioid use

• History of chronic pain

• History of obstructive sleep apnea

• Morbid obesity (Body Mass Index (BMI)>45 kg/m2)

• Height under 4' 10" (147 cm)

• Documented dural puncture by the epidural (Tuohy) needle

• Preeclampsia

• Other significant medical disease (American Society of Anesthesiologists (ASA) 3 or more).