Type 1 Diabetes, Endothelin, and Skeletal Muscle Mitochondrial Dysfunction: The Role of Sirtuin-1

• Status: Recruiting
• Trial end date: 2023-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The proposed study is designed to test the hypothesis that treatment of resveratrol for 12 weeks will improve both endothelin-B receptor (aim 1) and skeletal muscle mitochondrial function (aim 2) in people with type 1 diabetes.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Augusta University
• Treatments: Resveratrol

Criteria

Inclusion Criteria:

• Men and premenopausal women

• All races

• Clinical diagnosis of insulin-dependent type 1 diabetes (patients only)

Exclusion Criteria:

• Clinical diagnosis of hepatic, cardiovascular, or renal disease

• Uncontrolled diabetes (HbA1C >12%)

• Diabetic complications (i.e. neuropathy)

• Uncontrolled hypertension (>140/90 mm Hg on therapy)

• Pregnancy

• Use of vasoactive medications