In individuals with Type 2 Diabetes (T2D) it has been obtained an outstanding improvement in
the management of hyperglycemia, but it has not been achieved a similar result in the
reduction of the atherosclerotic syndrome. The comprehension of the mechanisms that link over
nutrition to inflammation and innate immune response can be important to understand the
relationship between insulin resistance, diabetes mellitus and endothelial dysfunction. It
will be investigated: 1) the role of Toll Like Receptors (TLR)s in the pathophysiology of T2D
and associated atherosclerosis; 2) the role of aspirin and nicotinamide adenine dinucleotide
phosphate (NADPH) oxidase inhibitor/s in the production of TxA2 and F2-isoprostanes in T2D
patients; 3)new biomarkers associated to Diabetes and atherosclerosis including markers of
endothelial dysfunction and cytokines.
It will be analyzed in isolated platelets from normal controls and/or diabetic patients the
production of TxA2, isoprostanes and pro-inflammatory/thrombotic cytokines using aspirin and
NADPHoxidase inhibitors.