Typhoid Fever: Combined vs. Single Antibiotic Therapy

• Status: Unknown status
• Trial end date: 2015-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The current study goal is to examine the effect of Cephalosporins, Azithromycin and the combination of both on typhoid fever therapy in endemic population.

The investigator's hypothesize that the combination of azithromycin and ceftriaxone may prove superior to each drug, ceftriaxone or azithromycin, alone.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Sheba Medical Center
• Treatments: Anti-Bacterial Agents; Antibiotics, Antitubercular; Azithromycin; Cefixime; Ceftriaxone

Criteria

Inclusion Criteria:

• Blood culture-proven typhoid fever (S. typhi or S. paratyphi)

• Signed informed consent to participate in the study.

Exclusion Criteria:

• Allergy to ceftriaxone or macrolides

• Major typhoid fever-associated complications

• Inability to swallow oral medication

• Underlying illness

• Pregnancy

• Lactation

• Treatment within the past 4 days with an antibiotic that may be effective against typhoid fever