Overview

Typical Versus Atypical Antipsychotics; Occupation of Striatal Receptors and the Appearance of Extrapyramidal Symptomatology, in Healthy Volunteers

Status:
Unknown status

Trial end date:
2011-12-01

Target enrollment:

Participant gender:

Summary

The purpose of this study is to determine in healthy volunteers treated with typical or atypical antipsychotics -AP-, the relationship between genetic polymorphisms in cytochrome genes CYP2D6 (*3, *4, *5, *6 and Nxn) and CYP3A5 (*3) with antipsychotic pharmacokinetics, occupancy of striatal dopaminergic receptors and the appearance of extrapyramidal symptomatology -EPS-.

Phase:

Phase 1

Details

Lead Sponsor:

Hospital Clinic of Barcelona

Collaborators:

Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Fundacion Clinic per a la Recerca Biomédica
University of Barcelona

Treatments:

Antipsychotic Agents
Haloperidol
Haloperidol decanoate
Risperidone