Ulipristal Acetate Versus GnRH Analogue Treatment Before Hysteroscopic Resection of Uterine Leiomyoma
Status:
Unknown status
Trial end date:
2017-09-01
Target enrollment:
Participant gender:
Summary
The uterine leiomyoma is the most common female benign disease. Submucosal fibroid are about
10%, they distort the endometrial cavity causing heavy and/or irregular bleeding (AUB) and
infertility. Hysteroscopic removal of submucosal myomas improves this conditions. GnRH
analogues are commonly used before hysteroscopic myomectomy to make surgery easier and safer,
but they are expensive, have potential side effects and lack a robust evidence base to
support this practice. Ulipristal acetate treatment was able and faster to control in 90% of
cases uterine bleeding associated with fibroids than GnRH agonists. UPA significantly
improved quality of life and pain reduction.