Ultradian Subcutaneous Hydrocortisone Infusion in Addison Disease and Congenital Adrenal Hyperplasia

• Status: Unknown status
• Trial end date: 2017-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to compare the effects of tablet treatment, circadian and combined circadian and ultradian subcutaneous hydrocortisone infusion on steroid metabolism and tissue responses to therapy.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Haukeland University Hospital
• Treatments: Cortisol succinate; Epinephrine; Epinephryl borate; Hydrocortisone; Hydrocortisone 17-butyrate 21-propionate; Hydrocortisone acetate; Hydrocortisone hemisuccinate; Racepinephrine

Criteria

Inclusion Criteria:

1. clinical diagnosis of primary adrenal insufficiency

2. Written informed consent

Exclusion Criteria:.

1. Diabetes mellitus

2. Severe cardiovascular disease

3. Active malignant disease

4. Pregnancy or breast feeding

5. treatment with interfering drugs

6. Intake of grapefruit juice