Ultrasound Evaluation of Lower Extremity Arteries After Topical Nitroglycerin Administration

• Status: Unknown status
• Trial end date: 2020-03-30
• Target enrollment: 0
• Participant gender: All

Summary

There have not been any published studies showing the use of topical nitroglycerin on the dilatory effect on the posterior tibial or dorsalis pedis arteries. The objective of this study is to determine the response of the posterior tibial artery and dorsalis pedis artery to topical administration of nitroglycerin. This study may provide further information for the utility of this artery in the treatment of peripheral arterial disease.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Deborah Heart and Lung Center
• Treatments: Nitroglycerin

Criteria

Inclusion Criteria:

• Patients admitted to Deborah Heart & Lung Center.

• Patients 18 years of age and older.

Exclusion Criteria:

• Patients who do not have the ability to provide informed written consent.

• Patients with documented allergy to Nitroglycerin

• Recent/chronic use of nitrates/vasodilatory medications.

• Patients with a SBP <100, labile blood pressure, tachycardia, hemodynamic instability.

• Patients with recent admission requiring antibiotics.

• Patients who are pregnant or nursing.

• Patients who have current or chronic liver, renal, rheumatologic, or neurological disease. - Patients who have had peripheral vascular procedures in the prior 30 days.

• Patients who have had any procedure or operation during their current hospitalization.