Ultrasound-guided Axillary Plexus Block - Dose Reduction of Prilocaine

• Status: Completed
• Trial end date: 2010-04-01
• Target enrollment: 0
• Participant gender: All

Summary

Clinical aim: Does reducing the dose of local anesthetic in ultrasound-guided axillary plexus anesthesia have any effect on the success rate and additional parameters of block quality? Methodology: In this prospective cohort study three groups of 40 outpatients each were administered dosages of 1% prilocaine of either 40mL, 30mL or 20mL for axillary plexus anesthesia. Met-Hb was measured prior to administration of the block and then hourly until the Met-Hb concentration fell. Parameters of block quality and any adverse effects were recorded. The level of significance was defined with α ≤ 0.05.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Helios Research Center
• Treatments: Midazolam; Prilocaine

Criteria

Inclusion Criteria:

• elective surgery on the distal forearm or the hand

• adult outpatients, age 18-75 years old

• ASA-risk groups I-II (American Society of Anesthesiologists)

• Body Mass Index 17-35

• informed consent

Exclusion Criteria:

• severe coagulopathy

• local or systemic inflammatory response

• ASA-risk groups ≥ Grad III

• severe anemia

• heart failure

• manifest shock

• other drugs with influence on methaemoglobinemia (nitrates, sulfonamides etc.)

• domestic care after surgery not ensured

• drug allergy : local anesthetics

• severe polyneuropathy

• pregnancy, lactation period

• participation in other studies

• non-cooperative patients

• addiction to drugs or alcohol