Ultrasound of the Knee in Obese Patients With Knee Osteoarthritis; Weight Maintenance
Status:
Completed
Trial end date:
2019-03-01
Target enrollment:
Participant gender:
Summary
This is a substudy to a randomised trial investigating the effect of liraglutide on body
weight and pain in overweight or obese patients with knee osteoarthritis (OA) (NCT02905864).
In the parent trial, patients will be subjected to an 8-week diet intervention phase
including a low-calorie diet and dietetic counseling, after which patients will be randomised
to receive either liraglutide 3 mg or liraglutide 3 mg placebo as an add-on to dietetic
guidance on re-introducing regular foods and a focus on continued motivation to engage in a
healthy lifestyle.
This substudy aims to investigate the impact of, and subsequent change of, joint inflammation
and clinical symptoms, in obese patients with knee osteoarthritis following a randomisation
to Liraglutide 3 mg or Liraglutide 3 mg placebo treatment between weeks 0-52.