Uncomplicated Nausea and Vomiting in the Emergency Department

• Status: Completed
• Trial end date: 2006-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Nausea and vomiting is a common complaint in the emergency department. Treatment is important for many reasons. In addition to patient comfort, there are adverse effects secondary to vomiting such as dehydration, metabolic alkalosis, Mallory-Weiss tears, and aspiration. Two mediations common used for nausea in ED patients include Ondanesetron and Metoclopramide.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: WellSpan Health
• Treatments: Metoclopramide; Ondansetron

Criteria

Inclusion Criteria:

• 18 years or older with nausea and at least 1 episode vomiting in the last 12 hours presenting to the York Hospital Emergency Department

Exclusion Criteria:

• Patients known to have hypersensitivity to the drugs ondansetron or metoclopramide

• gastrointestinal hemorrhage, mechanical obstruction or perforation

• patients with pheochromocytoma

• seizure disorder

• patients receiving other drugs which are likely to cause extrapyramidal reactions such as butapherones and phenothiazines

• patients experiencing hyperemesis gravidum

• patients unable to understand the informed consent (intoxicated, Spanish speaking)

• prior antiemetics within 12 hours

• inability to perform visual analog scale

• renal dialysis