Understanding Acute Sarcopenia

• Status: Unknown status
• Trial end date: 2021-09-01
• Target enrollment: 0
• Participant gender: All

Summary

This study aims to characterise acute changes in muscle mass, strength, physical performance in hospitalised older adults. We will assess the impact of these changes upon physical function at three month follow-up, and assess for the impact of clinical and immune-endocrine factors upon these changes.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Birmingham
• Collaborators: Dowager Countess Eleanor Peel Trust; MRC-Arthritis Research UK Centre for Musculoskeletal Ageing Research; University Hospital Birmingham NHS Foundation Trust
• Treatments: Anti-Bacterial Agents

Criteria

Inclusion Criteria:

ELECTIVE COHORT

• Aged 70 years or older at time of recruitment

• Expected to undergo an elective major colorectal surgery procedure

EMERGENCY SURGERY COHORT

• Aged 70 years or older at time of recruitment

• Emergency admission

• Expected to undergo emergency abdominal procedure during admission, or emergency abdominal procedure performed within previous 48 hours

MEDICAL COHORT

• Aged 70 years or older at time of recruitment

• Emergency admission for acute bacterial infection or presumed acute bacterial infection

Exclusion Criteria:

ELECTIVE COHORT

• Unable to provide written informed consent at time of recruitment

• Unable to understand verbal English

• Life expectancy less than 30 days

EMERGENCY SURGERY COHORT

• Unable to provide written informed consent at time of recruitment and no consultee available

• Unable to understand verbal English

• Life expectancy less than 30 days

MEDICAL COHORT

• Unable to provide written informed consent at time of recruitment and no consultee available

• Unable to understand verbal English

• Life expectancy less than 30 days