Understanding Cognition, Oxytocin & Pain in Elders
Status:
Recruiting
Trial end date:
2023-06-30
Target enrollment:
Participant gender:
Summary
Osteoarthritis (OA) represents a significant cause of disability worldwide and the knee is
the most commonly affected joint. Oxytocin (OT) is a mediator of endogenous analgesia in
animal and human studies. This proposal will test the efficacy and safety of
self-administered intranasal OT over 4-weeks in older individuals relative to placebo (P)
evaluating its effects on pain and function in aging and testing potential underlying
neurobiological mechanisms.