Understanding Rebound Pain After Regional Anesthesia Resolution in Healthy Volunteers

• Status: Completed
• Trial end date: 2024-05-28
• Target enrollment: 0
• Participant gender: All

Summary

Regional anesthesia decreases postoperative pain scores and opioid consumption, and may prevent chronic pain after surgery in patients undergoing surgery. However, some patients experience an increase of pain into the severe range when the nerve block wears off, also known as rebound pain. The investigators are studying if a nerve block (numbing injection) in the arm causes hyperalgesia (increased pain) when the nerve block is wearing off.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Brigham and Women's Hospital
• Treatments: Mepivacaine; Prilocaine

Criteria

Inclusion Criteria:

• Age ≥ 18 years old, ≤ 65 years old

• BMI >18, < 35

• Able to speak and understand English

• Willingness to undergo psychophysical testing (e.g., QST, pain questionnaires)

• Willingness to have nerve block performed

Exclusion Criteria:

• Ongoing acute or chronic pain in upper extremities

• Skin or tissue infection affecting upper extremities

• Previous hypersensitivity to mepivacaine or lidocaine

• Previous neuropathy (numbness, paresthesia, or motor weakness) in either upper extremity

• Loss of any limb

• Bleeding issues or bleeding disorder

• History of alcohol or drug abuse

• Currently pregnant or breastfeeding

• History of seizure or epilepsy