Uric Acid, Klotho and Salt Sensitivity in Young Adults Born Preterm

• Status: Recruiting
• Trial end date: 2025-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this research is to learn about how salt in the diet influences blood pressure in young adults who were born prematurely.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Wake Forest University Health Sciences
• Collaborators: National Heart, Lung, and Blood Institute (NHLBI); National Institutes of Health (NIH)
• Treatments: Allopurinol; Uric Acid

Criteria

Inclusion Criteria:

• Born 1990-1998

• Singleton birth

• Born at less than 34 weeks gestational age (preterm cohort)

• Born at greater than 36 weeks gestational age (term cohort)

Exclusion Criteria:

• Twin birth

• Congenital anomalies or genetic syndromes

• Currently pregnant or breast feeding

• Subject-reported history of hypertension

• Current use of antihypertensive medications

• Active cancer

• Chronic kidney disease

• Heart failure

• Liver failure