Uric Acid and the Endothelium in CKD

• Status: Completed
• Trial end date: 2016-09-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will test the hypothesis that uric acid impairs the function of vessels in patients with kidney disease

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Colorado, Denver
• Collaborators: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); National Institutes of Health (NIH)
• Treatments: Allopurinol; Uric Acid

Criteria

Inclusion Criteria:

• Individuals with moderate chronic kidney disease (CKD stage III) with estimated glomerular filtration rates between 30-60 mL/min/ 1.73m2

• Elevated uric acid levels

• Age range: more than 18 years old

• Ability to give informed consent

• Albumin > 3.0 g/dL

• BMI < 40 kg/m2

Exclusion Criteria:

• Life expectancy < 1.0 years

• Expected to undergo living related kidney transplant in 6 months

• Pregnant, breast feeding, or unwilling to use adequate birth control

• History of severe liver disease

• History of severe congestive heart failure

• History of hospitalizations within 3 months

• Active infection, on antibiotics

• History of Warfarin Use or other medications that are contraindicated with allopurinol

• Uncontrolled hypertension

• History of acute gout on Allopurinol

• History of adverse reaction to Allopurinol

• Immunosuppressive therapy within the last 1 yr