Urinary Aquaporin 2 Excretion After Methylprednisolone in Fasting Healthy Humans

• Status: Completed
• Trial end date: 2007-02-01
• Target enrollment: 0
• Participant gender: All

Summary

We wanted to test the hypotheses that methylprednisolone up regulates u-AQP-2 in fasting healthy humans

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Regional Hospital Holstebro
• Treatments: Methylprednisolone; Methylprednisolone Acetate; Methylprednisolone Hemisuccinate; Prednisolone; Prednisolone acetate; Prednisolone hemisuccinate; Prednisolone phosphate

Criteria

Inclusion Criteria:

• (1) Genders; both mal and female

• (2) Age; 18- 65 years old

• (3) BMI; below 30

• (4) Females had to bee in oral contraceptive treatment

Exclusion Criteria:

• (1) Clinical signs or history of disease in the heart, lungs, kidneys or endocrine organs

• (2) Abnormal laboratory test (blood haemoglobin, white cell count, platelets, plasma sodium, plasma potassium, plasma creatinine, plasma albumin, plasma bilirubin, plasma alanine aminotransferase, plasma cholesterol and blood glucose)

• (3) Albuminuria or glucosuria

• (4) Cancer

• (5) Arterial hypertension

• (6) Alcohol abuse

• (7) Use of tobacco

• (8) Medical treatment, except oral contraceptives

• (9) Pregnancy or breast feeding

• (10) Medicine abuse

• (11) Donation of blood less than 1 month before the study.