Urinary Bactericidal Activity of 4 Doses of Levofloxacin Against Fluoroquinolone-Resistant E. Coli
Status:
Completed
Trial end date:
2006-11-01
Target enrollment:
Participant gender:
Summary
Single-dose studies of a fluoroquinolone are indicative of their antimicrobial activity since
little accumulation occurs with multiple doses. Single-dose studies have been utilized to
determine drug concentrations and time kill activity in serum, urine, and respiratory
tissues.
The purpose of this study is to evaluate the Urine Bactericidal Activity (UBA) of
levofloxacin (250, 500, 750, and 1000 mg) against FQ-resistant, ESBL positive E. coli
isolates. In addition, a susceptibility breakpoint concentration in the urine can also be
established for each dose of levofloxacin. Furthermore, urine concentrations and serum
pharmacokinetic parameters of levofloxacin can be determined.