Use of Adenosine to Determine the Electrophysiological Mechanism of Premature Ventricular Contractions

• Status: Recruiting
• Trial end date: 2022-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Unblinded, controlled, non-randomized, mechanistic study to determine whether physiological mechanisms underlying PVC are sensitive to adenosine. One hundred subjects undergoing clinically-indicated, standard-of-care cardiac electrophysiology study (EPS) procedure for PVCs will receive adenosine and/or verapamil to learn if their arrhythmias are inducible similarly to sustained ventricular tachycardia.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Weill Medical College of Cornell University
• Treatments: Adenosine; Verapamil

Criteria

Inclusion Criteria:

• Diagnosis of premature ventricular contractions (PVCs)

• Scheduled to undergo an electrophysiology study with the intention of performing cardiac ablation for the treatment of PVCs

• Male or female between the ages of 18 and 70 years

• Capable of giving informed consent

Exclusion Criteria:

• Any structural heart disease

• Coronary artery disease (≥ 70% stenosis)

• Current treatment with anti-arrhythmic drugs

• Pregnant

• Asthma (if administering adenosine)