Use of Curcumin in the Lower Gastrointestinal Tract in Familial Adenomatous Polyposis Patients

• Status: Withdrawn
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to assess if curcumin, a commonly used food spice, can regress colorectal adenomatous polyps in patients with familial adenomatous polyposis, an inherited form of colorectal cancer.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Johns Hopkins University
• Treatments: Curcumin

Criteria

Inclusion Criteria:

• Familial adenomatous polyposis

• 18 years of age or older

• 5 or more adenomas of colorectum or ileum

Exclusion Criteria:

• Female patient of child bearing age not on effective birth control pills

• Pregnant women

• White blood cell (WBC) count less than 4000

• Platelets (Plts) less than 100,000

• Blood urea nitrogen (BUN) greater than 25

• Creatine greater than 1.5

• Patients unable to stop non-steroidal anti-inflammatory drugs (NSAIDs) during duration of trial

• Malignancy

• Patient with active bacterial infections of gastroesophageal reflux disease or peptic ulcer disease

• Patient on warfarin or anti-platelet drugs