Use of Estriol at Distal Third of Vagina Improving Coital Pain in Post-menopause Women
Status:
Unknown status
Trial end date:
2019-01-31
Target enrollment:
Participant gender:
Summary
Hypoestrogenism leads to vaginal wall changes resulting in diminished vaginal lubrication
and, consequently, causing pain during intercourse. Topical estrogen therapy (THT) may
control this complaint. However, there are limitations on its use, especially in patients
with breast cancer and diagnosed endometrial cancer. This randomized clinical trial aims to
assess the impact of local estriol therapy in postmenopausal women complaining of coital pain
and to assess serum concentrations of estriol in these women after estriol use.
One-hundred-thirty-two women aged between 40 and 65 years will be randomized into three
groups: Women using estriol 1 mg / 1g at the proximal third of vagina every other night -
estriol proximal group (PEG), women in using estriol 1 mg / 1g at the distal third of the
vagina every other night - estriol distal group (DEG), gel group (GG) using water-based
during intercourse.