Use of Granulocyte Colony-stimulating Factor for the Treatment of Recurrent Implantation Failure in IVF Patients

• Status: Unknown status
• Trial end date: 2013-03-01
• Target enrollment: 0
• Participant gender: Female

Summary

The investigators use granulocyte colony-stimulating factor (GCSF) for the treatment of recurrent implantation failure in IVF patient with cause unknown or due to thin endometrium. Several studies showed that GCSF improves embryo development and implantation and increase pregnancy rate.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Hadassah Medical Organization
• Treatments: Lenograstim

Criteria

Inclusion Criteria:

1. women after 5 failures in IVF cycles with cause unknown.

2. women after 5 failures in IVF due to thin endometrium (<6 mm) and unresponsive to estrogen supplements.

Exclusion Criteria:

1. history of hematology disease

2. allergy to GCSF

3. neutrophilia

4. severe lower back pain

5. liver dysfunction

6. hyperuricemia

7. a recent febrile disease or pneumonia

8. rheumatoid arthritis 9. sickle cell disease-