Use of HA 330-II for Hemofiltration in Patients With ALF as a Bridge to Liver Transplantation .
Status:
Recruiting
Trial end date:
2020-12-31
Target enrollment:
Participant gender:
Summary
ALF (ALF) is defined by three criteria: (1) rapid development of hepatocellular dysfunction
(jaundice, coagulopathy), (2) hepatic encephalopathy, and (3) absence of a prior history of
liver disease.
Interval between onset of acute hepatic injury (jaundice) and onset of liver failure
(encephalopathy with or without coagulopathy) in such patients (icterus-encephalopathy
interval; IEI) has been described to be between 4 weeks (Indian definition) to 24 weeks
(AASLD-ALF study group). Further, due to the diverse natural course, ALF has been
sub-classified as hyperacute (IEI ≤ 7 day), acute (IEI ≤ 4 weeks) and sub-acute ALF (IEI ≥ 5
week to ≤12 weeks) by British authors.