Use of High Resolution Colonic Manometry in Studying Motility
Status:
Withdrawn
Trial end date:
2018-12-25
Target enrollment:
Participant gender:
Summary
An injury to the spinal cord (SCI) results in numerous medical complications, including
gastrointestinal (GI) function. Individuals with SCI may experience severe constipation
(prolonged stool retention), incontinence (accidents), and overall difficulty in bowel
evacuation. While various treatments and medications have been established to address this
complication, there is little knowledge relating to the overall colonic motility. However,
new technology such as High Resolution Colonic Manometry allows physicians to visualize high
pressure contractions inside the colon, leading to a greater understanding of typical
motility, a more accurate diagnosis, and an effective treatment. In this study, the
investigators propose to use this technology to understand the effects of SCI on colonic
motility by comparing to normal colonic function observed in able-bodied (AB) individuals. In
addition, the investigators plan to study the effects of pharmacological treatments, such as
neostigmine, on promoting peristaltic contractions in the colon as it is delivered across the
skin.