Use of Hyperpolarized Xenon Gas for Lung Imaging in Children and Adults

• Status: Recruiting
• Trial end date: 2024-08-24
• Target enrollment: 0
• Participant gender: All

Summary

The goal of this study is to evaluate the usefulness of hyperpolarized (HP) 129Xe (xenon) gas MRI for regional assessment of lung function in a normal population of children and adults and in adults and also in children with respiratory compromise due to a variety of diseases.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Children's Hospital Medical Center, Cincinnati
• Treatments: Xenon

Criteria

Inclusion Criteria:

• Ages 6 and up

• Participant must be able to hold breath for up to 16 seconds

Exclusion Criteria:

• History of heart defect

• Pregnancy or positive pregnancy test

• History of uncontrolled asthma defined for this study as requiring use of rescue inhaler ≥ 2 times in past month

• Symptoms of respiratory infection (loose or productive cough or wheeze), chest tightness, or sinus infection within past week

• Baseline oximetry at MRI visit of less than 95% on room air or less than 95% on a previously prescribed dosage of oxygen delivered by nasal cannula

• Participant is claustrophobic and unable to tolerate the imaging.

• Standard MRI exclusions (metal, implants)