Use of Intranasal Oxytocin During Detoxification of Crack Cocaine

• Status: Recruiting
• Trial end date: 2020-05-31
• Target enrollment: 0
• Participant gender: Female

Summary

Randomized treatment control trial, double-blind, parallel, with two arms including ninety-six hospitalized women between 18 and 52 years. Those who agree to participate in the study and meet the eligibility criteria will be randomly allocated to one of the following experimental conditions:

• Conventional oxytocin treatment (T + OC): 32 female cocaine users hospitalized for detoxification will receive six 4 IU jets of intranasal oxytocin twice daily (daily dose of 48 IU) as adjunctive treatment to conventional treatment from the eighth to seventeenth day of hospitalization (duration of oxytocin treatment of 10 days). Conventional treatment includes supportive individual and group psychotherapy (once a week), nutritional control, regular physical activity and psychopharmacotherapy as needed to relieve the symptoms of anxiety, aggression and agitation typical of withdrawal and care. 21 days of hospitalization.

• Conventional treatment with placebo administration (T + PBO): 32 female cocaine users hospitalized for detoxification will receive six jets of placebo solution (2% odor-generating propolis essence + the same vehicle as intra-nasal oxytocin: 0.05% citric acid, 0.9% sodium chloride, 1% glycerol, 0.54% disodium phosphate, 0.2% methylparaben + propylparaben, 1% sorbitol, 80% water) twice daily as adjunctive treatment to conventional treatment from the eighth to the seventeenth day of hospitalization (duration of placebo treatment of 10 days). Conventional treatment includes supportive individual and group psychotherapy (once a week), nutritional control, regular physical activity and psychopharmacotherapy as needed to relieve the symptoms of anxiety, aggression and agitation typical of withdrawal and care. 21 days of hospitalization.

• Conventional treatment (T): 32 female cocaine users hospitalized for detoxification will receive conventional treatment including individual and group supportive psychotherapy (once a week), nutritional control, regular physical activity and psychopharmacotherapy if needed for symptom relief. anxiety, aggression and agitation, typical of abstinence and nursing care, during 21 days of hospitalization.

Outcomes: Withdrawal symptoms, Anxiety symptoms and Depressive symptoms

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Pontificia Universidade Católica do Rio Grande do Sul
• Collaborators: Conselho Nacional de Desenvolvimento Científico e Tecnológico; Secretaria Nacional de Políticas sobre Drogas (SENAD)
• Treatments: Cocaine; Oxytocin

Criteria

Inclusion Criteria:

• Volunteers (no payment to be enroll in the research according with Brazilian legislation)

• Age 18-52 years

• Primary diagnosis of cocaine crack dependence according to DSM-5

• Sex feminine

• Participants must be abstinent at least 7 days prior the study intervention

• Participants must consent to be randomly allocated to experimental conditions

Exclusion Criteria:

• Pregnancy

• Puerperium

• Breastfeeding

• Menopause

• Currently using hormone therapy

• Total hysterectomy

• Diagnosis or suspicion of autoimmune or neurological diseases and / or syndromes (stroke, Parkinson and Alzheimer's)

• Diagnosis or suspected current decompensated and / or severe endocrine, cardiovascular, pulmonary, renal, gastrointestinal disorders

• Moderate or severe psychotic syndrome

• Obesity Level III

• Intellectual impairment (IQ <70)

• Corticosteroid therapy, glucocorticoid or any exogenous steroid therapy

• Infectious condition or acute febrile syndrome

• Significant nasal congestion

• Type III nasal septum deviation (cases considered severe with deviated septum in which breathing is impaired)

• Mucosal lesions

• History of head trauma moderate or severe (Glasgow <12)

• HIV +