Use of Intrathecal Fentanyl and Development of Hyperalgesia in Patients Undergoing Elective Cesarean
Status:
Unknown status
Trial end date:
2016-01-01
Target enrollment:
Participant gender:
Summary
Opioid analgesic drugs are the main treatment of patients during anesthesia. Although highly
effective, their use is not without problems. One is the increasing requirement of these
address the same nociceptive stimulus.
Opioid induced hyperalgesia could be an explanation studies in animal models. Through
mechanisms where N-methyl-D-aspartate receptors, glutamatergic system disturbances and
changes in intracellular calcium regulation involved.
The hyperalgesia induced by intrathecal opioids is controversial. The investigators propose a
model study in patients undergoing cesarean section to study the secondary hyperalgesia
induced based on the study of nociceptive thresholds with two methods opioids: Von Frey
filaments and digital algometer.
If intrathecal fentanyl is used in spinal anesthesia for elective cesarean section, then, an
increase in sensitivity will occur. This increase can be measured by von Frey filaments,
expressed in increased requirement clinically opioids.