Use of Letrozole Pretreatment With Misoprostol for First-Trimester Medical Abortion

• Status: Completed
• Trial end date: 2015-09-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to compare the success rate of letrozole and misoprostol versus misoprostol alone for medical termination of first trimester pregnancy.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Ain Shams University
• Treatments: Letrozole; Misoprostol

Criteria

Inclusion Criteria:

• Maternal age more than 18 years old (age of legal consent).

• Gestational age less than 13 weeks.

• Hemoglobin >10 g/dL.

• BMI between 25 kg/m2 and 35 kg/m2.

• Missed abortion.

• Living fetus with multiple congenital malformations incompatible with life.

Exclusion Criteria:

• Maternal age less than 18 years old.

• Gestational age more than 12 weeks.

• Hemoglobin <10 g/dL.

• Anencephaly.

• Fibroid uterus.

• BMI less than 25kg/m2 and more than 35kg/m2.

• Coagulopathy.

• History or evidence of adrenal pathology.

• Previous attempts for induction of abortion in the current pregnancy.

• Allergy to misoprostol or letrozole.

• Medical disorder that contraindicate induction of abortion (e.g. heart failure).