Use of NPH Versus Basal Bolus Insulin for Steroid Induced Hyperglycemia
Status:
Terminated
Trial end date:
2019-08-15
Target enrollment:
Participant gender:
Summary
Glucocorticoids are known to cause an increase in insulin resistance, leading to
hyperglycemia, in both diabetic and non-diabetic patients. In both the inpatient and
outpatient setting, steroids are used for their anti-inflammatory property to treat a variety
of conditions. There is a paucity of information regarding the best way to treat
steroid-induced hyperglycemia. In this study we will compare (1) the addition of NPH insulin,
an intermediate-acting insulin, given at the time of steroid administration to the patient's
standard basal/bolus insulin to (2) modification of the standard basal-bolus insulin regimen
which will consist primarily increasing the prandial doses at lunch and supper in order to
determine which regimen is superior for glycemic control.