There is still no effective treatment for surgical pain, especially visceral pain in
bariatric surgery. Oxycodone has great application prospect in patients with obesity, but
there are few clinical studies and analgesic effect is still unclear, especially in
combination with esketamine.
This study was a prospective, single-center, randomized, controlled, double-blind clinical
trial to compare the efficacy and safety of intravenous oxycodone and combined use of
esketamine for perioperative multimodel analgesia during bariatric surgery, and the effect of
esketamine on inflammatory factors.
This study was based on the hypothesis that oxycodone and the combination use with esketamine
can effectively reduce the level of postoperative pain and inflammatory factors, and does not
increase perioperative adverse reactions in bariatric surgery.