Use of Oxygen in Heart Failure With Preserved Ejection Fraction

• Status: Completed
• Trial end date: 2017-02-15
• Target enrollment: 0
• Participant gender: All

Summary

Oxygen is routinely given to patients with common conditions such as COPD and heart failure. There is no evidence behind giving oxygen to patients specifically in heart failure due to a stiff heart.

This study aims to explore the effect oxygen has on the ability of patients with chronic heart failure and the ability to exercise. Other common variables will be assessed such as heart rate and blood pressure to observe the response to varying concentrations of oxygen.

The concentrations chosen are commonly offered in hospitals and indeed are being delivered through standard equipment found in all hospitals in the country.

It is hoped that studying the effect of short term oxygen on patients with heart failure will help to identify the effectiveness of oxygen in longer term therapy for patients who are often breathless with a decreased exercise tolerance.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hull and East Yorkshire Hospitals NHS Trust; Hull University Teaching Hospitals NHS Trust

Criteria

Inclusion Criteria:

• Over 50 years of age and able and willing to give consent

• Have signs and/or symptoms of heart failure

• Left ventricular ejection fraction > 45%

• NT-pro BNP > 220 pg/ml (in the previous 12 months)

• On any diuretic

Exclusion Criteria:

• Unable or unwilling to give consent

• Recent (<1 month) acute myocardial infarct or cerebrovascular event

• Significant renal dysfunction (eGFR <30 ml.min-1.1.73m-2)

• Significant anaemia (Haemoglobin < 100 g.L-1)

• Systolic blood pressure <90 mmHg, or >180 mmHg

• Severe mitral or aortic valve disease

• Diagnosis of severe chronic lung disease

• Involvement in another medicinal trial within the past four weeks

• Unable to use cycle

• Any planned admission in the following 3-4 weeks (patient can be reconsidered for enrolment after planned admission)