Use of Sitagliptin for Stress Hyperglycemia or Mild Diabetes Following Cardiac Surgery
Status:
Terminated
Trial end date:
2016-08-01
Target enrollment:
Participant gender:
Summary
This is a randomized controlled trial to determine the safety and efficacy of Sitagliptin in
patients with stress hyperglycemia or mild diabetes following cardiac surgery. Patients will
receive Sitagliptin or placebo. Sitagliptin may be of particular use in this patient
population due to the effects on hepatic glucose production (a major feature of SH), safety
(lack of contra-indications for heart failure or renal failure and no hypoglycemia), and
tolerability. The secondary objective of this study is to determine whether the management of
patients with persistent insulin requirements following cardiac surgery differs among
patients with stress hyperglycemia or mild diabetes.