Use of Testosterone to Prevent Post-Surgical Muscle Loss - Pilot Study
Status:
Enrolling by invitation
Trial end date:
2022-06-30
Target enrollment:
Participant gender:
Summary
The loss of muscle mass post-surgery confounds recovery efforts and leads to a delay in
patient's ability to return to activities. Although the use of testosterone in aging and
chronic muscle loss has been investigated, this study could prove short-term use of
testosterone efficacious in preventing muscle atrophy due to surgery. We hypothesize that by
bracketing an indexed knee surgery with testosterone undecanoate injections, post-surgical
quadriceps muscle loss may be minimized. Determination of the effect of intra-muscular (IM)
testosterone injections in preventing quadriceps muscle loss are measured by serial MRI and
manual measurements of quadriceps cross-section.
Phase:
Phase 2/Phase 3
Details
Lead Sponsor:
The Stone Research Foundation for Sports Medicine and Arthritis