Use of Topical Solasodine of Solanum Melongena Peel Origin in the Treatment of Palmar Arsenic Keratosis

• Status: Active, not recruiting
• Trial end date: 2021-01-15
• Target enrollment: 0
• Participant gender: All

Summary

Arsenic is one of the largest mass poisonings in Bangladesh. Arsenic keratosis of the palm and sole is a common feature of arsenicosis. Brinjal or eggplant ubiquitous vegetable found in different parts of the world, including Bangladesh, scientifically known as Solanum melongena. A study showed ointment containing crude extract of Solanum melongena peel origin is effective in arsenic keratosis. Solasodine is one of the active compounds of Solanum melongena peel. In the current study, an ointment containing a single compound solasodine isolated from Solanum melongena peel . The ointment made from solasodine extract was distributed among arsenic keratosis patients to see the effect.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

Criteria

Inclusion Criteria:

• Presence of moderate to severe palmar arsenical keratosis

• Drinking arsenic-contaminated water for at least six months

• Patient voluntarily agreed to participate

Exclusion Criteria:

• Age less than 18 years or more than 60 years

• Pregnant and nursing mother

• Skin diseases like atopic dermatitis eczema and psoriasis

• Patient allergic to brinjal (eggplant)

• Patient taken any treatment of arsenicosis for the last six months