Use of Tranexamic Acid in Reduction of Post-Op Complications in Mohs Micrographic Surgery

• Status: Not yet recruiting
• Trial end date: 2022-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate the use of locally injected tranexamic acid (TXA) under the skin during Mohs micrographic surgery for removal of skin cancers in patients on anticoagulation. TXA may be helpful in reducing bleeding and pain during surgery, and may also lead to fewer post-operative complications following surgery such as graft loss, specifically in patients on blood-thinners.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Riley McLean
• Treatments: Epinephrine; Lidocaine; Tranexamic Acid

Criteria

Inclusion Criteria:

• Must be on systemic anticoagulation therapy (indirect or direct anticoagulants or anti-platelet agents)

• Must be scheduled for Mohs surgery at the University of Massachusetts Department of Dermatology

Exclusion Criteria:

• History of hypercoaguable disorder (e.g. Factor V Leiden Deficiency)

• History of deep vein thrombosis or pulmonary embolism

• Systolic blood pressure greater than 200 on day of surgery

• Known allergy to TXA

• Currently taking systemic retinoids

• Unable to consent

• Pregnant women

• Prisoners