Use of Transexamic Acid in Hip Replacement

• Status: Unknown status
• Trial end date: 2016-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Studies have shown that tranexamic acid reduces blood loss and transfusion need in patients undergoing total hip arthroplasty. However, no to date, no study has been large enough to determine definitively whether the drug is safe and effective. The present study was designed to verify noninferior efficacy and safety of topical intra-articular TXA compared with intravenous TXA in primary THA.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Samsung Medical Center
• Treatments: Tranexamic Acid

Criteria

Inclusion Criteria:

• Unilateral primary THA

• Diagnosis - not fracture, elective surgery

• Revision THA

Exclusion Criteria:

• Known allergy to TNA

• Acquired or congenital coagulopathy

• Current anticoagulation therapy

• Preoperative hepatic or renal dysfunction

• Severe ischemic heart disease (Serious cardiac or respiratory disease)

• A history of thromboembolic disease

• Refusal of blood products

• Pregnancy or breastfeeding