Use of Vagitories Based on St. John's Wort, Tea Tree Oil and Shepherd's Purse in the Treatment of Vaginal Inflammation

• Status: Completed
• Trial end date: 2019-09-30
• Target enrollment: 0
• Participant gender: Female

Summary

There are more and more herbal preparations that are used for the purpose of treatment and improvement of the clinical picture of vaginitis by patients themselves, but also by healthcare professionals. Plant species, St. John's wort, chamomile, calendula, yarrow, shepherd's purse and tea tree oil are well known for there anti-inflammatory, antimicrobial and wound healing activity. This paper presents the results of a clinical study in which three herbal formulations/vagitories, based on extracts of above mentioned plant species, were investigated for their effectiveness on non-specific vaginitis.

This was randomized controlled clinical study that included 210 women with diagnosed non-specific vaginitis. Patients were divided into two basic groups, women in reproductive stage and postmenopausal stage. Three subgroups, containing approximately 30 patients each, received one of three vagitorie formulations for 5 days during which the effects on subjective and objective symptoms were monitored.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Sarajevo
• Collaborators: Institution for Health Protection of Women and Motherhood; University of Tuzla
• Treatments: Tea Tree Oil

Criteria

Inclusion Criteria:

• adult women who already had sexual intercourse

• diagnosis of non-specific vaginal inflammation by medical examination.

Exclusion Criteria:

• microbiologically confirmed bacterial vaginosis,

• treatment with antibiotic therapy according to official protocols and guidelines

• allergies to one of the plant species included in the vaginal test,

• diabetes mellitus,

• pregnancy,

• lactation,

• immunodeficiency disorder,

• severe chronic illness,

• previous radiotherapy, chemotherapy and biological therapy