Use of a Loading Dose of Vancomycin in Pediatric Dosing

• Status: Terminated
• Trial end date: 2012-03-01
• Target enrollment: 0
• Participant gender: All

Summary

Vancomycin is an antibiotic administered to children or adults for many types of infections. While it has been used to treat infections of children for more than 50 years we are still not completely certain about the best dose to use when starting treatment with this medication.

This study is intended to evaluate whether giving a new higher dose of vancomycin for the first dose will help us get to the desired amount in the body more quickly then the usual first dose. Half of the patients would get the new higher dose and the other half of patients will get the typical first dose. Only the first dose is changed and all doses that follow are the same in both groups and are doses typically used for children.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Boston Children's Hospital; Boston Children’s Hospital
• Treatments: Vancomycin

Criteria

Inclusion Criteria:

• Receiving care at Children's Hospital Boston

• Prescribed intravenous vancomycin by their physician

Exclusion Criteria:

• Weight above 67 kg

• Pre-existing renal dysfunction (creatinine clearance < 50 ml/min/1.73m2)

• Known hearing impairment

• Recent intravenous vancomycin treatment (within 7 days)

• Undergoing procedure with anticipated moderate-severe blood loss