Use of the xCELLigence System for Quantification of Bacterial Biofilm's Real Time Formation and Antibiotics Selection.

• Status: Unknown status
• Trial end date: 2019-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of the study is to develop an in vitro model of growth of oral biofilms, and validate xCELLigence system for the selection of an effective antibiotic treatment for each patient.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Valencia
• Collaborators: Centro Superior de Investigación en Salud Publica; Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
• Treatments: Anti-Bacterial Agents; Antibiotics, Antitubercular

Criteria

Inclusion Criteria:

1. Subjects of 40-70 years.

2. No smokers or smokers of less than 10 cigarettes a day.

3. Patients with periodontitis stages III and IV grades A-B.

4. Presence of 20 natural teeth, including at least three molar teeth.

5. Presence of at least 4 sites with at least 6 mm probing depth.

6. Good general health

Exclusion Criteria:

1. Smokers of more than 10 cigarettes a day.

2. Patients who have received periodontal treatment in the previous 12 months.

3. Patients who have used antibiotics in the last 6 months.

4. Routine use of oral antiseptics and / or during the previous 3 months.

5. Systemic conditions that required antibiotic premedication.

6. Women pregnant or nursing.

7. Medications that could influence the outcome of periodontal therapy.

8. Any known allergies to the test antimicrobial agents.

9. Diabetics.