Usefulness of Exhaled Breath Condensate for Evaluation of Markers of Airway Inflammation in Children With Asthma
Status:
Unknown status
Trial end date:
2014-06-01
Target enrollment:
Participant gender:
Summary
Exhaled breath condensate (EBC) has emerged as a novel noninvasive technique for assessment
of airway inflammation, and it provides information on airway lining fluid composition.
Traditionally, such assessment relies on invasive diagnostic tools such as bronchial biopsy
and bronchoalveolar lavage (BAL) to obtain specimens from the airway but it is very
uncomfortable procedure especially for young patients. The aim of this study is to evaluate
the effect of allergic disease, disease monitoring and exposure to tobacco smoke on airway
inflammation measured by markers in exhaled breath condensate (EBC) in children with asthma
allergic to house dust mite. Also, we aim to assess correlations between cytokine
concentrations in EBC and clinical characteristic of the patients with exercise-induced
bronchoconstriction as another phenotype of asthma.
Phase:
Phase 2
Details
Lead Sponsor:
Medical University of Lodz Medical Universtity of Lodz