Using Furosemide to Prevent Fluid Overload During Red Blood Cell Transfusion in Neonates

• Status: Unknown status
• Trial end date: 2009-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to investigate the effects of intravenous furosemide on cardio-respiratory performance in neonates receiving a packed red blood cell (PRBC) transfusion who are considered at high risk of volume overload.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The Hospital for Sick Children
• Treatments: Furosemide

Criteria

Inclusion Criteria:

• Less than 44 weeks corrected gestational age

• Receiving a red cell transfusion

• Satisfy one of the following criteria:

• Echocardiographic evidence of a hemodynamically significant ductus arteriosus (HSDA) defined by a transductal diameter >1.5 mm and unrestrictive systemic-pulmonary trans-ductal flow

• Clinical evidence of significant lung disease defined by a need for respiratory support (assisted ventilation or nasal CPAP) and oxygen supplementation after 28 days of age

Exclusion Criteria:

• Infants with multiple congenital anomalies or renal insufficiency

• Infants with hypotension, hypertension, or on any cardiac medication

• Infants with sepsis causing compromised clinical condition such as disseminated intravascular coagulopathy

• Infants with contra-indications to diuretic therapy, such as significant electrolyte imbalance, or endocrine disease