Using Magnetic Resonance (MR) to Understand the Effect of Erythromycin on Bowel Motility
Status:
Completed
Trial end date:
2012-03-01
Target enrollment:
Participant gender:
Summary
Magnetic Resonance Imaging (MRI) has proven to be a valuable imaging technique for suspected
small bowel disease. This technique depends, in part, on adequate distension of the small
bowel. This is accomplished by administering large volumes of a non-absorbable oral contrast
material prior to the examination, which typically produces excellent distension of the
distal small bowel and stomach, but poor distension of the proximal small bowel. Erythromycin
is a common antibiotic that is known to promote stomach emptying and is used to treat
diabetics with gastroparesis (poor stomach emptying.) The hypothesis of this study was that
erythromycin will increase gastric emptying and hence improve small and large intestinal
distention during MRI.
Phase:
Phase 2/Phase 3
Details
Lead Sponsor:
Mayo Clinic
Collaborator:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)