Using Platelet Rich Plasma in Reducing Alveolar Bone Resorption During Rapid Maxillary Expansion

• Status: Completed
• Trial end date: 2018-07-15
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine if the injection of Platelet-rich plasma (PRP) is effective in reducing alveolar bone loss that happens after each rapid maxillary expansion (RME) on the buccal aspect of the posterior teeth.

16 patients with a skeletal maxillary constriction aged between 10-16 years old will get into orthodontic treatment to widen the maxilla using Hyrax appliance.

An amount of patient blood will be withdrawn and centrifuged to get PRP. Then the PRP will be injected in one half of each patient mouth in a split-mouth design, beneath the buccal periosteal of the first molars and first premolars, the halves will be chosen randomly.

High resolution CBCT images will be taken before and after orthodontic treatment to analyze buccal bone thickness and height changes.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Damascus University

Criteria

Inclusion Criteria:

• 10-16 years old patients

• Complete emergence of first molars and first premolars

• Clinical maxillary transverse deficiency

• Good oral hygiene (Gingival index <1) according to Silness & loe 1964

• ( Plaque index <1)

Exclusion Criteria:

• The presence of a medical situations that affects orthodontic treatment and periodontal health

• The presence of drug therapy affect orthodontic treatment and periodontal health

• Bad oral hygiene (gingival and plaque index >1)

• Patient with physical and psychological limitations

• Metallic restorations or endodontic treatments on the appliance supporting teeth (first molars and first premolars)

• Craniofacial anomalies

• Previous orthodontic treatment

• Patients who did not correctly follow the protocol of activation

• Patients who did not return for control dental appointments

• Patients whose cementation of the appliance failed

• Patients whose dental structures were difficult to visualize on the CBCT scans as a result of artifact