Using Propranolol in Traumatic Brain Injury to Reduce Sympathetic Storm Phenomenon

• Status: Completed
• Trial end date: 2017-08-01
• Target enrollment: 0
• Participant gender: All

Summary

Traumatic Brain Injury (TBI) is one of the leading causes of death. Severe TBT is correlated with an exaggerated stress response due to plasma catecholamine levels known as sympathetic storming. It is also autonomic dysfunction syndrome. This phenomenon is also associated with brain tumors, severe hydrocephalus and subarachnoid hemorrhage. Patients are presented by tachycardia, tachypnea hypertension, diaphoresis, dystonia, hyperthermia, and dilated pupils with elevated levels of plasma catecholamine and blood glucose .

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ain Shams University
• Treatments: Propranolol

Criteria

Inclusion criteria:

• Patients with isolated blunt TBI

• From 18 to 60 years old both sex

• Not in need of mechanical ventilation

• GCS on admission between 9 and 12

• Rotterdam CT score from 2-4.

• Normal Procalcitonin test to exclude infection.

Exclusion criteria:

• Preexisting heart disease

• Myocardial injury

• Craniotomy

• Preexisting cerebral dysfunction

• Spinal cord injury

• Diabetes mellitus

• Severe liver or kidney disease

• Patients with sepsis